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Index > Protein center > VMP1(Gene name) > Human
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  • VMP1 (Gene name),
  • Vacuole membrane protein 1 (Protein name ),  VMP1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    VMP1(HSPC292;TDC1;TMEM49);
    Protein name:
    Vacuole membrane protein 1;
    Alternative:
    Transmembrane protein 49;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with BECN1. Interacts with TJP1.
    Function:
    Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions.
    Subcellular Location:
    Endoplasmic reticulum-Golgi intermediate compartment membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Vacuole membrane Multi-pass membrane protein Endoplasmic reticulum
    Protein Attributes:
    Sequence length:
    406
    Sequence:
    50:
    MAENGKNCDQ | RRVAMNKEHH | NGNFTDPSSV | NEKKRREREE | RQNIVLWRQP | 
    100:
    LITLQYFSLE | ILVILKEWTS | KLWHRQSIVV | SFLLLLAVLI | ATYYVEGVHQ | 
    150:
    QYVQRIEKQF | LLYAYWIGLG | ILSSVGLGTG | LHTFLLYLGP | HIASVTLAAY | 
    200:
    ECNSVNFPEP | PYPDQIICPD | EEGTEGTISL | WSIISKVRIE | ACMWGIGTAI | 
    250:
    GELPPYFMAR | AARLSGAEPD | DEEYQEFEEM | LEHAESAQDF | ASRAKLAVQK | 
    300:
    LVQKVGFFGI | LACASIPNPL | FDLAGITCGH | FLVPFWTFFG | ATLIGKAIIK | 
    350:
    MHIQKIFVII | TFSKHIVEQM | VAFIGAVPGI | GPSLQKPFQE | YLEAQRQKLH | 
    400:
    HKSEMGTPQG | ENWLSWMFEK | LVVVMVCYFI | LSIINSMAQS | YAKRIQQRLN | 
    406:
    SEEKTK
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Vacuole membrane protein 1
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    ELISA Kit for Human Vacuole membrane protein 1
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    ELISA Kit for Human Vacuole membrane protein 1
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    CLIA Kit for Human Vacuole membrane protein 1
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    U14852b
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    Packing:
    96T
    CLIA Kit for Human Vacuole membrane protein 1
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    U14852m
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    Packing:
    96T
    CLIA Kit for Human Vacuole membrane protein 1
    Cat.:
    U14852r
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    Packing:
    96T
    CLIA Kit for Human Vacuole membrane protein 1
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    U14852h
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    Packing:
    96T
    Polyclonal Antibody for Human Vacuole membrane protein 1
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    P14852Rb-m
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    40ug/0.2ml
    Polyclonal Antibody for Human Vacuole membrane protein 1
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    Polyclonal Antibody for Human Vacuole membrane protein 1
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    Packing:
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    Polyclonal Antibody for Human Vacuole membrane protein 1
    Monoclonal Antibody for Human Vacuole membrane protein 1
    Monoclonal Antibody for Human Vacuole membrane protein 1
    Monoclonal Antibody for Human Vacuole membrane protein 1
    Monoclonal Antibody for Human Vacuole membrane protein 1
    Protein for Human Vacuole membrane protein 1
    Protein for Human Vacuole membrane protein 1
    Protein for Human Vacuole membrane protein 1
    Protein for Human Vacuole membrane protein 1

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    References
    1. 1.
      "Gene Tdc1 is a transmembrane domain containing gene that amplified and overexpressed in human breast cancer."
      Wu G. , Couch F.J.
      Submitted (1999-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "A novel lipopolysaccharide-inducible gene (#25)."
      Yamazaki S. , Muta T. , Takeshige K.
      Submitted (2000-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Kidney.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Spleen.
    5. 5.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Ovary.
    7. 8.
      "Human partial CDS from CD34+ stem cells."
      Ye M. , Zhang Q.-H. , Zhou J. , Shen Y. , Wu X.-Y. , Guan Z.Q. , Wang L. , Fan H.-Y. , Mao Y.-F. , Dai M. , Huang Q.-H. , Chen S.-J. , Chen Z.
      Submitted (1999-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 243-406 (ISOFORM 1)
      tissue: Blood.
    8. 9.
      "Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells."
      Sauermann M. , Sahin O. , Sultmann H. , Hahne F. , Blaszkiewicz S. , Majety M. , Zatloukal K. , Fuzesi L. , Poustka A. , Wiemann S. , Arlt D.
      Oncogene27:1320-1326(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TJP1;SUBCELLULAR LOCATION
    9. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TP53INP2
    10. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
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